Drug Interaction and Biological Studies of Amantadine Derivatives

Amantadine an antiviral antiparkinsonian drug has cage like basic structure it is a colorless crystalline compound with a camphor-like odor. The interactions of amantadine with ACE-inhibitors cephalosporins essential and trace elements H1-receptor antagonists H2-receptor antagonists NSAIDs and quinolones was investigated in 0.1 N HCl. Amantadine complexes were synthesized with all interacting drugs and characterized by UV FTIR 1H-NMR and mass spectroscopy. The energy minimization study was carried out to determine the binding site of amantadine and along with these studies metal complexes of amantadine with (Mn Fe Cu Zn Ca Mg Cr Co Ni and Cd) were synthesized. The structures of these complexes were confirmed by IR NMR CHN elemental analysis and AA spectroscopy. Antiviral studies of amantadine-drug complexes evaluated through National institute of Infectious Diseases USA in Southern Research Institute Maryland USA. Against Biodefence viruses (Rift Valley Fever Tacaribe VEE Yellow Fever) Respiratory viruses ( RSV A Adeno PIV Rhinovirus Type 2 RSV A Flu A (H1N1) Flu A (H3N2) Flu A (H5N1) Flu B SARS)Herpes viruses (HSV-1 HSV-2 HCMV VZV EBV).