In 2017 the International Diabetes Federation (IDF) estimated that about 451 million of global population are affected by Diabetes and the numbers are increasing daily. Poly-pharmacy and Drug interactions are very common among diabetic patients as they may receive multiple medications to manage various co-morbid conditions such as Hypertension Dyslipidemia Heart diseases Depression Infections and many others along with their regular anti-diabetic medications. The risk of hypoglycemic complications might be increased in patients taking hypoglycemic agents along with the drugs inhibiting their metabolism or the drugs or herbs having hypoglycemic potentials. The healthcare professionals including Prescribers Pharmacists Diabetic educators and others should be aware of the drugs or herbs interacting with anti-diabetic medications to prevent Adverse drug interactions. As the paragraph reading is confusing and boring the mechanisms behind every drug interaction is depicted in schematic flow charts along with explanatory notes to ease the understanding of Readers.