Drug Repurposing and Computational Drug Discovery

<p>Drug repurposing is defined as identifying new pharmacological indications from old existing failed investigational already marketed or FDA-approved drugs and prodrugs and applying these new uses in the treatment of diseases other than the drug’s original intended therapeutic use. The application of computational techniques in discovery research not only helps in the development of drugs from leads or existing drug molecules but can also be useful for the repurposing of existing drug candidates.</p><p>This new volume presents exciting recent advances in drug repurposing and computational approaches for the discovery and development of drugs against certain difficult-to-treat and life-threatening diseases. With contributions from a global team of experts (academicians scientists and researchers) it explores the sophisticated tools and techniques of drug repurposing and computational drug discovery. It delivers valuable information on computational techniques tools and databases being utilized for drug repurposing and for identifying the uses of existing drug candidates on different emerging or deadly diseases. Drug repurposing and computational approaches addressed in the book target the discovery and development of drugs for microbial infections (bacterial fungal viral COVID-19) parasitic diseases and neglected tropical diseases (NTDs) malignant diseases (cancer) inflammatory diseases cardiovascular disorders diabetes and aging and neurological (CNS) disorders. In addition the challenges and regulatory issues encountered in drug repurposing and computational drug discovery programs are looked at offering perspectives for future directions.</p>