Dual Drug Action of Drug Delivery System

The purpose of the present research was to produce a quick/slow biphasic delivery system for Diclofenac Sodium. A dual component tablet made of a sustained release tableted core and an immediate release tableted coat was prepared by direct compression. Both the core and the coat contained a model drug (Diclofenac Sodium). The sustained release effect was achieved with a polymer (Microcrystalline cellulose) to modulate the release of the drug. The in vitro drug release profile from these tablets showed the desired biphasic release behavior: the Diclofenac Sodium contained in the fast releasing component was dissolved within 2 minutes whereas the drug in the core tablet was released at different times (≈16 or 924 hours) depending on the composition of the matrix tablet. Based on the release kinetic parameters calculated it can be concluded that the Micro Crystalline core was suitable for providing a constant and controlled release (zero order) for a long period of time.