The underlying pathogenesis of many TCD remains unknown until now but recently studies have demonstrated that epigenetic modifications might induce and/or accelerate the development of auto-immunity. These modifications include alteration of DNA methylation chromatin remodeling and micro-RNAs which are the main focus of this book in which we discuss the involvement of epigenetics in two of the Connective tissue diseases: Rheumatoid arthritis (RA) and Systemic lupus erythematosus (SLE).
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