<p>Aircraft electrification is one of the most important and strategic initiatives currently supporting the innovation of the aviation industry. This manifests in the well-known more-electric aircraft concept (with the ultimate aim of achieving the all-electric long-term target) which aims&nbsp;to gradually replace onboard systems based on mechanical hydraulic or pneumatic power sources with electrically powered ones to reduce the weight and costs optimize energy and increase the eco-compatibility and reliability of future aircrafts.</p><p>A key technological enabler for pursuing these challenging objectives is electro-mechanical actuation. The applicability of electro-mechanical actuators (EMAs) in aerospace has been proved in terms of dynamic performances but it still entails several concerns in terms of reliability/safety and operation in a harsh environment. In civil aircrafts EMAs are often avoided for safety-critical functions (flight controls brakes landing gears and nose wheel steering) essentially because the statistical database on the components' fault modes is poor.</p><p>This Special Issue is thus focused on advancements and innovations in the design modelling/simulation architectural definition reliability/safety analysis control condition-monitoring and experimental testing of EMAs developed for safety-critical aerospace applications. The research papers included in this Special Issue will undoubtedly contribute to progress towards the objective of more electric flights.</p>