Epithelial-mesenchymal transition is a process that describes the development of motile. Recent studies indicate that the phenomenon of Epithelial-mesenchymal transition plays a key role in carcinoma aggressiveness. This book evaluates compares and correlates the immunohistochemical expression of β-cat MMP1 FN SNAI1 &TWIST2 as an epithelial-mesenchymal transition markers with tumor depth pattern of invasion eosinophilia mitosis and inflammatory cell intensity in oral squamous cell carcinoma.