Error-Tolerant Biochemical Sample Preparation with Microfluidic Lab-on-Chip

<p>Microfluidic biochips have gained prominence due to their versatile applications to biochemistry and health-care domains such as point-of-care clinical diagnosis of tropical and cardiovascular diseases cancer diabetes toxicity analysis and for the mitigation of the global HIV crisis among others. Microfluidic Lab-on-Chips (LoCs) offer a convenient platform for emulating various fluidic operations in an automated fashion. However because of the inherent uncertainty of fluidic operations the outcome of biochemical experiments performed on-chip can be erroneous even if the chip is tested a priori and deemed to be defect-free. This book focuses on the issues encountered in reliable sample preparation with digital microfluidic biochips (DMFBs) particularly in an error-prone environment. It presents state-of-the-art error management techniques and underlying algorithmic challenges along with their comparative discussions. </p><ul> <p> </p> <li>Describes a comprehensive framework for designing a robust and error-tolerant biomedical system which will help in migrating from cumbersome medical laboratory tasks to small-sized LOC-based systems </li> <p> </p> <li>Presents a comparative study on current error-tolerant strategies for robust sample preparation using DMFBs and reports on efficient algorithms for error-tolerant sample dilution using these devices </li> <p> </p> <li>Illustrates how algorithmic engineering cyber-physical tools and software techniques are helpful in implementing fault tolerance </li> <p> </p> <li>Covers the challenges associated with design automation for biochemical sample preparation </li> <p> </p> <li>Teaches how to implement biochemical protocols using software-controlled microfluidic biochips </li> </ul><p>Interdisciplinary in its coverage this reference is written for practitioners and researchers in biochemical biomedical electrical computer and mechanical engineering especially those involved in LOC or bio-MEMS design.</p>