Extracellular Matrix : ECM

The extracellular matrix (ECM) is a three-dimensional meshwork of proteins proteoglycans and polysaccharides imparting structure and mechanical stability tissues.    A network of high quality protein-protein interactions constructed from these core genes reveals the ECM is organised into biologically relevant functional modules whose components exhibit a mosaic of expression and conservation patterns.ECM dysfunction has been implicated in a number of debilitating conditions including cancer atherosclerosis asthma fibrosis and arthritis.  Identifying the components that comprise the ECM and understanding how they are organised within the matrix is key to uncovering its role in health and disease. This review defines role of Matrix Metalloproteinase -3 and Matrix Metalloproteinase -21 in cancer also rigorous protocol for Extracellular matrix’s components functions merits demerits and various biological activities.