The author has proposed GADV hypothesis on the origin of life suggesting that life emerged on the primitive Earth not from RNA world but from [GADV]-protein world which was formed by pseudo-replication of [GADV]-protein composed of Gly [G] Ala [A] Asp [D] and Val [V]! In parallel the origins of gene the genetic code and protein are comprehensively explained in the hypothesis mainly based on protein 0th-order structure or a specific amino acid composition in which water-soluble globular protein can be produced at a high probability even by random joining of amino acids.