Gene Regulation and Therapeutics for Cancer

<p>Differential gene regulation and targeted therapy are the critical aspects of several cancers. This book covers specific gene regulation and targeted therapies in different malignancies. It offers a comprehensive assessment of the transcriptional dysregulation in cancer and considers some examples of transcriptional regulators as definitive oncogenic drivers in solid tumors followed by a brief discussion of transcriptional effectors of the programs they drive and discusses its specific targets. Most targeted therapeutics developed to date have been directed against a limited set of oncogenic drivers exemplified by those encoding cell surface or cytoplasmic kinases that function in intracellular signaling cascades.</p>