Gene Regulation of Gene Expression in Human Genome

Gene Sequence of DNA or RNA which codes for molecule that has function. Product include: SiRNA rRNA miRNA tRNA mRNA. Gene Expression information from a Gene is used in the synthesis of functional gene products. Molecular Levels Level one:1-DNA 2-TranscriptionLevel Two - 1-RNA 2-Translation 3-RNACommon transcription factor motifs• Zinc finger • Helix-loop-helix (HLH) • Leucine zipper (LZ) • HMG box (high mobility group ) • Shared feature • Structurally stable framework • Specific DNA recognizing sequences are correctly positioned Repression of Transcription Cells also possess negative regulatory elementsMechanisms: • Binding to promoter elements. • Blocking assembly of the preinitiation complex. • Inhibiting binding or functioning of transcriptional activators. • Modifying DNA and its interaction with nucleosomes. Some transcription factors activate some genes and repress others.