Genetic Signatures for Progression and Response of Hepatitis C

The hepatitis C virus (HCV) the silent killer is endemic worldwide. Therefor finding novel signatures for HCV progression and response to anti-viral therapies is very important in terms of diagnosis and prognosis of the disease. P53 induces the expression of Fas for triggering apoptosis; an important mechanism for limiting viral replication. This study aims at investigating the impact of P53 rs 1042522 and Fas rs 1800682 genetic polymorphisms at 72 Arg/Pro and -670 A/G respectively on HCV susceptibility and treatment response. Quantitation of HCV-RNA by qRT-PCR and histological scores were performed for every patient as well as genotyping of HCV-RNA P53 at 72 Arg/Pro and Fas at -670 A/G polymorphisms were done for all subjects. In addition hormonal profiling for all patients and controls were investigated and correlated with the genetic signatures providing a strong multi-signatures for HCV progression and response.