Genetic Toxicology and Cancer Risk Assessment

<p>Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation!<br><br>This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification dose-response relationships exposure assessment and current practices of risk characterization.<br><br>Examines predictive values of mutagenicity tests mechanisms of carcinogenesis and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines!<br><br>Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study Genetic Toxicology and Cancer Risk Assessment</p><li>reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis <br> </li><li>calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens <br> </li><li>reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models <br> </li><li>discusses the threshold concept of carcinogenesis <br> </li><li>demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens <br> </li><li>considers structural activity relationship (SAR) analysis of chemical carcinogenicity <br> </li><li>describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays <br> </li><li>illustrates the use of genetic biomarkers for dosimetry analysis <br> </li><li>and more!<br>Linking human cancer genetics mutagenicity assays mechanisms of carcinogenesis carcinogenic thresholds molecular epidemiology mathematical modeling and quantitative cancer risk analysis Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive developmental cell and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate graduate and medical school students in these disciplines.</li>