The most important autoimmune diseases are rheumatoid arthritis (RA) and systemic lupus erythematous (SLE). Rheumatoid arthritis (RA) is a chronic progressive inflammatory autoimmune disease that is associated with articular extra-articular and systemic effects. Systemic lupus erythematous (SLE) is a disorder of immune regulation resulting in chronic inflammation that affects many organs with the production of autoantibodies.