Stress diet global warming and low level EMF pollution leads to endosymbiotic archaeal growth and civilizational disease. Most diseases in the modern world are in a sense consequent to environmental change related archaeal endosymbiosis and are treatable only to a limited extend. This forms the basic biology of medical nihilism and the limits of human capability in medical interventions. Gentle medicine encourages a moderate form of therapeutic conservatism and deals with modulating stress diet and life styles to treat civilizational diseases like metabolic syndrome x schizophrenia autism neurodegeneration autoimmunity and malignancies.