Handbook of Drug Metabolism

Bringing together nearly forty collaborators from academic and industrial laboratories this reference furnishes an overview of the subject from a historical kinetic and chemical context. A source of expertise for a rapidly changing and expanding field the book provides a framework for drug metabolism in drug discovery and development. Containing tables drawings photographs and equations it highlights the importance of pharmacokinetics and cytochrome P450 explains clearance volume of distribution sequential metabolism and nonlinear kinetics summarizes concepts of Phase 1 and 2 metabolites evaluates tertiary amine metabolism and reactive metabolite chemistry and more.