<p>This handbook on vacuolar and plasma membrane H+-ATPases is the first to focus on an essential link between vacuolar H+-ATPase and the glycolysis metabolic pathway to understand the mechanism of diabetes and the metabolism of cancer cells. It presents recent findings on the structure and function of vacuolar H+-ATPase in glucose promoting assembly and signaling in addition to describing the regulatory mechanisms of vacuolar H+-ATPase in yeast cells neural stem cells kidney cells cancer cells as well as under diabetic conditions. </p>
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