Handbook of Neurophotonics

<p>The <em>Handbook of Neurophotonics</em> provides a dedicated overview of neurophotonics, covering the use of advanced optical technologies to record, stimulate, and control the activity of the brain, yielding new insight and advantages over conventional tools due to the adaptability and non-invasive nature of light.</p><p>Including 30 colour figures, this book addresses functional studies of neurovascular signaling, metabolism, electrical excitation, and hemodynamics, as well as clinical applications for imaging and manipulating brain structure and function. The unifying theme throughout is not only to highlight the technology, but to show how these novel methods are becoming critical to breakthroughs that will lead to advances in our ability to manage and treat human diseases of the brain.</p><p><strong>Key Features:</strong></p><ul> <li>Provides the first dedicated book on state-of-the-art optical techniques for sensing and imaging across at the cellular, molecular, network, and whole brain levels.</li> <li>Highlights how the methods are used for measurement, control, and tracking of molecular events in live neuronal cells, both in basic research and clinical practice.</li> <li>Covers the entire spectrum of approaches, from optogenetics to functional methods, photostimulation, optical dissection, multiscale imaging, microscopy, and structural imaging.</li> <li>Includes chapters that show use of voltage-sensitive dye imaging, hemodynamic imaging, multiphoton imaging, temporal multiplexing, multiplane microscopy, optoacoustic imaging, near-infrared spectroscopy, and miniature neuroimaging devices to track cortical brain activity.</li> </ul> <p><strong>Contents</strong></p><p>Preface, ix</p><p>Contributors, xi</p><p>Part I <b>Function and Structural Neurophotonic Imaging</b></p><p>Chapter 1 ◾ Miniaturized Optical Neuroimaging Systems 3</p><p>Hang Yu, Janaka Senarathna, Betty M. Tyler, Nitis h V. Thakor, and Arvi nd P. Pathak</p><p>Chapter 2 ◾ Functional Imaging with Light-Sheet Microscopy 21</p><p>Raghav K. Chhetri and Philipp J. Keller</p><p>Chapter 3 ◾ Two-Photon Microscopy in the Mammalian Brain 55</p><p>Hod Dana and Shy Shoham</p><p>Chapter 4 ◾ Light Field Microscopy for <i>In Vivo </i>Ca2+ Imaging 81</p><p>Tobi as Nöbauer and Alip asha Vaziri</p><p>Chapter 5 ◾ Genetically Encoded Activity Indicators 113</p><p>Chenchen Song and Thomas Knöpfel</p><p>Chapter 6 ◾ Functional Optoacoustic Imaging 129</p><p>Daniel Razansky</p><p>Chapter 7 ◾ Imaging Deep in the Brain with Wavefront Engineering 147</p><p>Roarke Horstmeyer, Maximi llian Hoffmann, Haowen Ruan, Benjami n Judkewitz,</p><p>and Changhuei Yang</p><p>Chapter 8 ◾ Nanoscopic Imaging to Understand Synaptic Function 173</p><p>Daniel Choquet and Anne-Sophie Hafner</p><p>Chapter 9 ◾ Chemical Clearing of Brains 191</p><p>Klaus Becker, Chris tian Hahn, Nina Jährling, Marko Pende,</p><p>Inna Sabdyusheva-Litsc hauer, Saiedeh Saghafi, Martina Wanis , and Hans-Ulric h Dodt</p><p>Chapter 10 ◾ Advanced Light-Sheet Microscopy to Explore Brain</p><p>Structure on an Organ-Wide Scale 221</p><p>Ludovic o Silvestri and Francesc o S. Pavone</p><p>Part II <b>Neurophotonic Control and Perturbation</b></p><p>Chapter 11 ◾ Optogenetic Modulation of Neural Circuits 235</p><p>Mathias Mahn, Oded Klavi r, and Ofer Yizhar</p><p>Chapter 12 ◾ Molecular Photoswitches for Synthetic Optogenetics 271</p><p>Shai Berlin and Ehud Y. Isacoff</p><p>Chapter 13 ◾ Applications of Nanoparticles for Optical Modulation of</p><p>Neuronal Behavior 293</p><p>Chiara Pavi olo, Shaun Gietman, Daniela Duc, Sim on E. Moulton, and</p><p>Paul R. Stoddart</p><p>Chapter 14 ◾ Optical Stimulation of Neural Circuits in Freely Moving</p><p>Animals 317</p><p>Leore R. Heim and Eran Stark</p><p>Chapter 15 ◾ Holographic Optical Neural Interfaces (HONIs) 333</p><p>Shani Rosen, Shir Paluch, and Shy Shoham</p><p>Chapter 16 ◾ Multi-Photon Nanosurgery 353</p><p>Anna Letizia Allegra Masc aro and Francesc o Saverio Pavone</p><p>Part III <b>Clinical and Human Neurophotonics</b></p><p>Chapter 17 ◾ High Resolution Diffuse Optical Tomography of the</p><p>Human Brain 369</p><p>Muriah D. Wheelock and Adam T. Eggebrecht</p><p>Chapter 18 ◾ Human Brain Imaging by Optical Coherence Tomography 399</p><p>Caroline Magnain, Jean C. Augustinack, Davi d Boas, Bruce Fisc hl, Taner Akkin,</p><p>Ender Konukoglu, and Hui Wang</p><p>Chapter 19 ◾ Acousto-Optic Cerebral Monitoring 439</p><p>Mic hal Balberg and Revi tal Pery-Shechter</p><p>Chapter 20 ◾ Neurophotonic Vision Restoration 459</p><p>Adi Schejter Bar-Noam and Shy Shoham</p><p>Chapter 21 ◾ Optical Cochlear Implants 473</p><p>C.-P. Ric hter, Y. Xu, X. Tan, N. Xia, and N. Suematsu</p><p>Chapter 22 ◾ Label-Free Fluorescence Interrogation of Brain Tumors 503</p><p>Brad A. Hartl, Shami ra Sridharan, and Laura Marcu</p><p>Chapter 23 ◾ Higher Harmonic Generation Imaging for Neuropathology 527</p><p>Nikolay Kuzmi n, Sander Idema, Eleonora Aronic a, Philip C. de Witt Hamer,</p><p>Pieter Wess eling, and Marie Louis e Groot</p><p>INDEX, 545</p>