Hematopoietic Stem Cell Transplantation

<p>This book integrates recent advances in molecular and cell biology of hematopoietic stem cells (HSC) with developments in clinical research in stem cell-based therapy-providing an up-to-date review of novel cytokines and cellular components; animal models; cell preparation selection and collection; minimal residual disease and purging; expansion of progenitor cells; allogeneic and autologous transplantation; cellular gene and immunotherapy; and more. <br>Examines key areas for treatment with HSC including ambulatory care and monitoring regimen-related toxicities immunodeficiency and immunization infection chronic graft-versus-host and disease secondary malignancies and long-term quality of life.<br>Covering stem cell pool regulation and the complex interplay of extrinsic and intrinsic events Hematopoietic Stem Cell Transplantation </p><li>summarizes current understanding and development of clinical allogeneic HSC transplantation <br> </li><li>discusses the use of allogeneic transplantations with reduced conditioning regimen or mini-transplantation <br> </li><li>considers various strategies for mobilization of HSCs from peripheral blood (PB) of normal donors <br> </li><li>details detection of bone marrow contamination by tumor cells and removal procedures <br> </li><li>focuses on efforts to increase the ex vivo transduction efficiency of human HSCs with retroviral vectors <br> </li><li>explores the effects of growth factor administration and leukapheresis on PB stem cell donors <br> </li><li>shows the impact of CD34+ cell isolation and the relevance of expansion of HSC from bone marrow for clinical use <br> </li><li>reveals how minimal residue disease detection assays are crucial for tracking the clinical significance of infused tumor cells <br> </li><li>employs automated fluorescence image cytometry to study early HSC behavior following seeding<br>Incorporating contributions from over 90 researchers who cite more than 2180 references to encourage continued study</li>