Heterocyclic compounds especially pyrazolo[15-a]pyrimidines and 124-triazines exhibited various biological and pharmacological applications such as DNA binding anti-tubercular antiviral anti-inflammatory antioxidant antimicrobial and anticancer. Therefore the main objective of this book is to display the synthesis spectral analysis and biological evaluations of some pyrazolo[15-a]pyrimidines and 124-triazines.