Human Longevity

<p>More than 7 billion people inhabit the earth and all of them are subject to aging. This book is aimed at persons interested in a molecular explanation of how our cells age. <b>Human Longevity: Omega-3 Fatty Acids Bioenergetics Molecular Biology and Evolution </b>is built on the proposition that we age as our mitochondria age. It suggests a revised version of Harman’s famous hypothesis featuring mitochondrial oxidative and energy stresses as the root causes of aging. </p><p>Human cells are protected from the ravages of aging by a battery of defensive systems including some novel mechanisms against membrane oxidation introduced in this book. This concept is consistent with recent discoveries showing that mitochondria-targeted antioxidants prevent Huntington’s disease Parkinson’s disease and traumatic brain disease in animal models of neurodegeneration.</p><p>This book explores a unified theory of aging based on bioenergetics. It covers a variety of topics including an introduction to the science of human aging the Darwinian selection of membranes enabling longevity a revised mitochondrial membrane hypothesis of aging and various mechanisms that protect human mitochondrial membranes thereby enabling longevity.</p>