HYPOPHOSPHATEMIC OSTEOMALACIA

Diabetes phosphorus (DP) is a group of rare conditions characterized by renal phosphate leakage leading to hypophosphatemia and osteomalacia. Although PD-related osteomalacia is much rarer than vitamin D-related osteomalacia its etiologies are many and varied including genetic oncogenic and drug-related causes as well as tubulopathies. The diagnosis of PD is primarily a biological one based on hypophosphatemia associated with a low rate of tubular phosphorus reabsorption (TRP). Once the diagnosis has been made a thorough etiological work-up is required to identify the underlying cause plan treatment and prevent bone complications. This is based on biology metabolic imaging and if necessary a genetic study. The main objective is to find a curable etiology in particular an FGF-23-secreting tumour requiring surgical removal. In the absence of an identified cause PD is said to be idiopathic. Its management is medical based mainly on optimal phosphorus and calcitriol supplementation.