Impact of obesity on results of chemotherapy in breast cancer

The main goal of induction chemotherapy for locally advanced breast cancer is feasibility of radical surgery or breast conserving surgery. The achieve pathologic complete response is proven to be the most important parameter of prognosis. The most commonly used preoperative chemotherapy regimens in breast cancer include anthracyclines and taxanes. The reports evaluating the impact of obesity on the obtained pathologic response to chemotherapy are divergent This study was undertaken in patients with locally advanced breast cancer treated with induction chemotherapy based solely on AT (doxorubicin plus docetaxel) regimen. We analyzed the relationship of obesity and overweight with pathologic response to neoadjuvant chemotherapy and survival.