In Search of Selective 11��-HSD 1 Inhibitors without Nephrotoxicity

Over expression of 11β-HSD 1 in key metabolic tissues is related to the development of type 2 diabetes obesity hypertension and metabolic syndrome. Nephrotoxicity of corosolic acid (selective inhibitor of 11β-HSD 1) is recently reported which is one of the major drawback. Therefore it is of great interest to find out the selective 11β-HSD 1 inhibitors without nephrotoxicity. Using crystal structures of 11β-HSD 1 in complex with inhibitors as a source of structural information a combined structure-based virtual screening approach followed by PASS toxicity prediction Lipinski’s rule and ADME prediction implemented to find out the potent and selective 11 β-HSD 1 analog of corosolic acid without nephrotoxicity.