In Vitro Toxicity of Silver Nanoparticles in Human Lung Epithelial Cells

<p>Nanotechnology is quickly becoming incorporated into everyday products and uses. Silver nanoparticles specifically are being used in commercial products to include aerosols. The purpose of this research was to determine whether silver nanoparticles are toxic to human lung epithelial cells. Different types (coated vs. uncoated) concentrations (10 50 100 and 200?g/mL) and sizes (coated 5 and 80nm uncoated 10 and 80nm) of silver nanoparticles were used during this study. Toxicity measurements were completed through in vitro techniques. Another study was also completed on toxicity mechanisms by measuring the reactive oxygen species (ROS) generated. Results showed that silver nanoparticles induce mitochondrial toxicity through a size and concentration dependent manner. Increasing the concentration yielded increased toxicity and the smaller the size induced increased toxicity to the mitochondria. Results also showed that the uncoated nanoparticles were also more toxic to the cells than the coated nanoparticles. The small nanoparticles (coated 5 uncoated 10nm) induced more formation of the ROS than the larger nanoparticles (80nm).</p><p>This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact and remains as true to the original work as possible. Therefore you will see the original copyright references library stamps (as most of these works have been housed in our most important libraries around the world) and other notations in the work.</p><p>This work is in the public domain in the United States of America and possibly other nations. Within the United States you may freely copy and distribute this work as no entity (individual or corporate) has a copyright on the body of the work.</p><p>As a reproduction of a historical artifact this work may contain missing or blurred pages poor pictures errant marks etc. Scholars believe and we concur that this work is important enough to be preserved reproduced and made generally available to the public. We appreciate your support of the preservation process and thank you for being an important part of keeping this knowledge alive and relevant.</p>