Indomethacin Pulsatile Drug Delivery

Six formulations of modified pulsincap of Indomethacin were developed by using various grades and ratios by using Hydroxy propyl methyl cellulose K-100M CCS as rate controlling polymers. Magnesium sterate and talc are the other components used. Blends were evaluated for various parameters such as bulk density tapped densityangle of repose Hausners ratio Carr’s index. Capsules were evaluated for their physical appearancedrug content % weight variation and Invitro drug release. All the physico chemical properties are with in the acceptable limits. Based on the results formulation F6 containing HPMC-K100M in the concentration double the drug’s concentration was identified as an ideal and better formulation among all formulations. In-vitro release of an optimized formulation of Indomethacin (f6) was found to be 96.05% in 4hrs. Based on the regression coefficient (R2 ) values of various plots the optimized formulation was found to follow First-order release model and mechanism of drug release was non-fickian type of diffusion based on ‘n’ value of Korsemeyer-Peppas model.