Inhaled Steroids in Asthma

<p>This book sums up the mechanistic basis current status and future prospects of steroid inhalation as the cornerstone of prophylactic asthma therapy identifying its kinetic basis-especially the essential airway selectivity-and including a historical account of inhaled glucocorticoid development.<br>Makes connections among the underlying pharmacology impact of new simulation models newly recognized molecular targets and therapeutic outcomes of short- and long-term steroid inhalation therapy!<br>Containing more than 1600 works cited drawings tables equations and micrographs Inhaled Steroids in Asthma</p><li>describes the developmental history of inhaled steroids and provides general models for lung selectivity <br> </li><li>considers the best way to select inhaled steroids <br> </li><li>clarifies local metabolism airway and lung uptake and retention and other determinants of once-daily usage <br> </li><li>addresses variations in lung deposition and total bioavailability among available steroids and formulations <br> </li><li>surveys the dynamics of receptor gene-mediated processes <br> </li><li>analyzes the role of chemokines in airway allergic inflammatory diseases <br> </li><li>discusses the effects of inhaled steroids in vivo on cell progenitors in asthma and rhinitis <br> </li><li>details measuring airway inflammation as a guide for treatment decisions <br> </li><li>outlines the clinical relevancy of exhaled nitric oxide in asthma <br> </li><li>covers optimal trial design for judging antiasthmatic potency and efficacy <br> </li><li>evaluates the safety of inhaled steroids <br>Written by more than 40 of the world's leading authorities and investigators Inhaled Steroids in Asthma is an authoritative reference for pulmonologists and pulmonary disease specialists; physiologists; allergists; immunologists; molecular cell and lung biologists; pediatricians; pharmaceutical scientists and pharmacologists; and medical school and upper-level undergraduate graduate and medical school students in these disciplines.</li>