Insulin Resistance and Nephropathy in Type 2 Diabetic Patients

Diabetic nephropathy (DN) is a common and severe microvascular complication of type 2 diabetes mellitus (T2DM) that can result in end-stage renal disease (ESRD). On the other hand insulin resistance (IR) is strongly associated with obesity and had an important role in the pathogenesis and increased complicating of many human diseases such as diabetes which can be used as a biomarker of renal dysfunction in DN thus decreasing the mortality and morbidity. Hence taking into consideration the combination of obesity IR and T2DM may demonstrated excellent indicator for early-stage DN in patients with T2DM. In the present study we concluded that blood biomarkers (glucose insulin urea creatinine BMI GFR CrCl IR Hcy FA Cys C LC OPG SA Se Zn Mg) were emphatically connected with the nearness of nephropathy and they could be representing to indicators of renal impairment in DN. Moreover Urinary Alb NGAL 8-OHdG and FN and the combination of all four biomarkers demonstrated an excellent diagnostic value for early-stage of DN in patients with T2DM. The above explored clinical biomarkers must be used later on for early recognition of DN in people of T2DM and its intricacy.