Integrative Omics and Systems Pharmacology for COVID-19

<p>In 2019 the emerging RNA virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gained the ability to infect human beings then turned into human-to-human transmission and eventually led to a pandemic of coronavirus disease 2019 (COVID-19) causing serious damage not only to global public health but also economic activities for years. Now fast-mutating SARS-CoV-2 continues to produce new variants that threaten the world. As such there is still a high demand for the development of effective treatments for combating new variants of SARS-CoV-2 infection and mitigating diverse post-COVID symptoms including those who are long-COVID patients.</p><p>This book introduces cutting-edge ways for drug discovery and pharmacological approaches to develop treatments and medications for COVID-19 based on modern technologies that highlight the applications of integrated multiple omics and advanced bioinformatics tools. It also lists a range of promising bioactive compounds derived from traditional herbal medicines and natural products. The book explains the expanding strategy to integrate a series of approaches including genomics metagenomics transcriptomics proteomics metabolomics epigenomics and bioinformatics to organize a system of multiple omics. International and reliable multi-omics databases bioinformatics tools and software are also comprehensively summarized and thus can be easily accessed by researchers. Artificial intelligence (AI) as a revolutionary tool in the fields of drug discovery vaccine development and computational medicine for COVID-19 is also addressed. The coordination and integration of AI tools within the system of multiple omics and the limitations and future directions of AI-assisted strategies for COVID-19-related research are comprehensively discussed as well.</p>