Investigation of Cytokine Gene Polymorphism in Dengue Hemorrhagic Fever

Observing the current context in relation to the lack of control of successive dengue epidemics in Brazil as well as the rapid territorial expansion of Aedes Aegypti we foresee the possibility of outbreaks and/or epidemics of Dengue Hemorrhagic Fever (DHF) and as a result we will also see an increase in its lethality given the current situation of our national health system. We know that some diseases present different immune responses in the face of polymorphism in cytokine genes. In this study we seek to identify genetic factors related to the worsening of the disease in patients with DHF. This investigation focuses on the possibility of polymorphism in cytokine genes: TNF-α -308 G→A TGF-β codon 10 and codon 25 IL-10 -1082 G→A -819 C→T -592 A→C IL-6 -174G→C and IFN-γ +874 T→A with FHD. We hope to contribute to the discovery of new paths in the search for a better understanding of this pathology that affects thousands of people worldwide.