Lamotrigine Tablets

Epilepsy is a common chronic neurological disorder characterized by recurrent unprovoked seizures. While traditional anticonvulsant drugs are primarily antimanic agents lamotrigine is recognized as one of the most effective drugs for the treatment and prophylaxis of bipolar depression. Two novel drug delivery systems were developed for lamotrigine: orally disintegrating tablets (ODTs) and sustained release tablets (SRTs). ODTs are particularly useful for pediatric and geriatric patients as well as for those who have difficulty swallowing providing rapid onset of action to control emergencies. In contrast sustained release tablets offer the advantage of reduced dosing frequency by prolonging drug action. In this project both ODTs and SRTs of lamotrigine were prepared using simple methods to address different therapeutic needs in epilepsy management.