<p><span style=color: rgba(23 43 77 1)>Coronavirus disease 2019 (COVID-19) has undeniably led to the worst worldwide healthcare outbreak of the twenty-first century. Our understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 virus) the agent that causes COVID-19 has dramatically improved over the past several years. Currently healthcare systems are facing another COVID-19 outbreak in the form of long COVID or post-COVID-19 syndrome-that is the development and presence of long-lasting symptoms after an acute SARs-CoV-2 infection. To date more than 100 potential long-lasting post-COVID symptoms have been attributed to SARS-COV-2. This Special Issue which is entitled Latest Research in Post-COVID (Long-COVID): Pathological and Treatment Studies of Sequelae and Complications as part of the journal&nbsp;</span><em style=color: rgba(23 43 77 1)>Biomedicines</em><span style=color: rgba(23 43 77 1)> focuses on potential gaps regarding the identification timeframe mechanisms and treatment strategies associated with the management of this post-COVID-19 condition. The issue includes fourteen published papers covering the following topics: (1) treatment of this post-COVID-19 condition; (2) neonatal repercussions of SARS-CoV-2 infection; (3) risk factors of severe COVID-19; (3) phenotyping of post-COVID pain; and (5) other topics.</span></p>