LIFE AND SCIENCE lowered levels of sperm

<p>It's a gem that our awesome publishing company has brought to</p><p>life. Now as part of my job I get to dive into countless books and I must</p><p>say this one is an absolute delight. No need for any unnecessary delay let</p><p>me give you a sneak peek into what makes it so worthwhile. Are you ready?</p><p>Let's jump right in with the introduction Age-related endocrine disruption</p><p>has been linked to cognitive decline and an increased risk of</p><p>neurodegenerative illnesses as evidenced by a growing body of research.</p><p>Although oestrogens have long been thought to safeguard brain function it</p><p>was only recently discovered that androgens and luteinizing hormone can</p><p>affect cognitive processes by altering how we learn and remember things.</p><p>Improving treatment for cognitive impairment linked to the hypothalamicpituitary-</p><p>gonadal axis requires a deeper understanding of the underlying</p><p>mechanisms. In this article we highlight the role of reproductive hormones</p><p>in preserving brain health and amplifying signalling cascades that lead to</p><p>Preface</p><p>mental decline. We discuss the endocrine changes that occur with age their</p><p>role in the onset of Alzheimer's disease and the therapeutic potential of</p><p>endocrine manipulation in preventing cognitive decline in the</p><p>elderly.Menopause oophorectomy oestrogen testosterone memory loss </p><p>Alzheimer's disease and luteinizing hormone are all terms of interest.The</p><p>risk of age-related neurodegenerative disorders like Alzheimer's disease</p><p>(AD) is increasingly important to think about as the baby boomer</p><p>generation ages and life expectancy increases thanks to medical</p><p>advancements. By 2050 it's expected that over 13 million people would</p><p>have been diagnosed with AD. Dementia is one of the most expensive</p><p>diseases with annual costs of care for people with Alzheimer's disease and</p><p>other forms of dementia estimated at over $180 billion in the United States</p><p>alone. As the prevalence of neurodegenerative diseases increases so too</p><p>will the emotional mental and financial strains placed on those who</p><p>provide care for those who have been diagnosed.Amyloid- senile plaques </p><p>neurofibrillary tangles made of aggregated tau and hippocampal cell loss</p><p>are the classic neuropathologies of Alzheimer's disease. Clinically AD is</p><p>distinguished by memory and attention difficulties which deteriorate into</p><p>problems with reasoning communication and direction as the disease</p><p>advances. Although oxidative stress inflammation and neuronal</p><p>dysfunction have all been implicated in the development of Alzheimer's</p><p>disease conclusive data explaining disease pathogenesis is lacking; as a</p><p>result we and others have been forced to look beyond these basic</p><p>pathologies in search of other molecular cues driving AD pathogenesis.The</p><p>effect of gonadal hormones on cognition in the elderly has been the subject</p><p>of substantial research. Hormones are known to impact CNS function and</p><p>stability.