Lifetime Exposure to Arsenic in Drinking Water- Application to a Bladder Cancer Case-Control Study

Ingestion of arsenic in drinking water has been linked with the risk of bladdercancer however questions remain about the dose-response relationshipsranges in induction-latency intervals and whether there are critical lifetimeexposure periods of heightened susceptibility. This book describes how individual-level estimates of arsenic exposure are reconstructed using newlydeveloped Space-Time Information System technology and offers methodologicalapproaches for evaluating temporal dynamics in the relationshipbetween arsenic exposure and bladder cancer. Spatial temporal and spatiotemporalvariability are incorporated in the assessment of lifetime exposureto arsenic. Fluid and food consumption data are joined with mobilityhistories and arsenic concentrations to generate a detailed lifetime assessmentof arsenic exposure. These exposure estimates will be used in apopulation-based bladder cancer case-control study nearing completion insoutheastern Michigan. This work is directed to exposure scientists environmentalepidemiologists health geographers GIScientists and othersinterested in the links between environment human health and spatial technology.