Links between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges


LOOKING TO PLACE A BULK ORDER?CLICK HERE

Piracy-free
Piracy-free
Assured Quality
Assured Quality
Secure Transactions
Secure Transactions
Fast Delivery
Fast Delivery
Sustainably Printed
Sustainably Printed
Delivery Options
Please enter pincode to check delivery time.
*COD & Shipping Charges may apply on certain items.
Review final details at checkout.

About The Book

Tissue fibrosis may occur for unknown causes or be the consequence of many pathological conditions including chronic inflammatory or infectious diseases autoimmune disorders graft rejection or malignancy. On the other hand malignant tumors have been identified in fibrotic tissues decades ago and now accumulating evidence suggests that fibrotic lesions enhance the risk of cancer in several organs such as liver lungs and breast. Disruption of an organ parenchymal cells and of its normal structural scaffold during tissue fibrogenesis appears to induce loss of cell polarity promoting uncontrolled cell proliferation that may eventually lead to cancer development. Many cellular and molecular abnormalities including aberrant expression of microRNAs genetic and epigenetic alterations evasion or delayed apoptosis unregulated intracellular signal pathways and dysregulation or defective intercellular communications have been proposed to explain this link between fibrogenesis and carcinogenesis. However the precise mechanisms of this fibrosis-to-cancer transition remain unclear. This book presents a collection of reviews and original articles summarizing recent advances in understanding the molecular mechanisms of cancer development in fibrotic organs.
downArrow

Details