Lipid Microspheres for Controlled Release of Lipid Soluble Drug

In the present work we aimed our investigation to prepare and evaluate the Lipid microspheres of an Anti-inflammatory drug i.e. Aceclofenac in order to control the drug release to enhance the bioavailability and to minimize gastrointestinal side effects. For the preparation of Lipid microspheres melt dispersion technique was used. Paraffin wax and stearic acid were used as excipients. The prepared Lipid microspheres formulations were evaluated for different parameters like particle size analysis drug content entrapment efficiency and SEM XRD DSC and invitro release studies.