Management of Sickle Cell Disease in sub-Saharan Africa

Sickle cell disease (SCD) poses a major public health challenge in sub-Saharan Africa. Nigeria being the most populous black nation in the world bears its greatest burden in sub-Saharan Africa. The last few decades has witnessed remarkable scientific progress in understanding of its complex patho-physiology. However improved clinical insights have heralded development and establishment of disease modifying interventions such as chronic transfusions; hydroxyurea and bone marrow transplant. Coupled with parallel improvements in general supportive symptomatic and preventive therapies current evidence reveals remarkable appreciation in quality of life among affected individuals in developed nations. However in most West African states treatment is largely sub-optimal. Thus this text provides a current review on SCD management with emphasis on local patterns/peculiarities particularly from a Nigerian perspective. Established treatment guidelines as appropriate in the West African setting are proffered as well as recommendations for improved care of affected persons.