<p>(Mass spectrometric) non-target screening is a preferably comprehensive and untargeted (predominantly organic molecules detecting) approach combining (robust) analytical measurements with adapted data evaluation concepts systematic compound identification workflows and statistical data interpretation.&nbsp;It is well suitable for the identification of new unexpected and/or unknown organic compounds as well as monitoring 'molecular fingerprints' and profiling 'process-relevant' molecules via statistical methods. In recent years 14 articles in various disciplines were published and presented in this Special Issue whereby it contains 4 peer-reviewed review articles and 10 peer-reviewed research articles dealing with non-target screening strategies and solutions.</p>
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