<p>The mechanical behavior&nbsp;of&nbsp;biomedical materials and biological tissues are important for their proper function. This holds true not only for&nbsp;biomaterials&nbsp;and tissues whose main function is structural such as skeletal tissues and their synthetic substitutes but also for other tissues and&nbsp;biomaterials. Moreover there is an intimate relationship between&nbsp;mechanics&nbsp;and biology at different spatial and temporal scales. It is therefore important to study the mechanical behavior&nbsp;of&nbsp;both synthetic and livingbiomaterials. This Special Issue aims to serve as a forum for communicating the latest findings and trends in the study&nbsp;of&nbsp;the mechanical behavior&nbsp;of&nbsp;biomedical materials.</p>