Fast dissolving tablet of Metoprolol Tartrate using superdisintegrants

Metoprolol Tartrate is a ?-blocker drug indicated for the treatment of angina prevention of myocardial infarction Essential hypertension; It has low bioavailability of about 40% due to hepatic metabolism. The purpose of this research was to improve the bioavailability by preparing a fast dissolving tablet using superdisintegrants method. Because pregastric absorption of drug improves bioavailability gives rapid onset of action when needed.