Medicinal chemistry

SYNTHESIS AND CHARACTERIZATION OF 35- DIMETHYL PYRAZOLEAIM: To synthesize 35- dimethyl pyrazole in the laboratory and characterize the crude and re-crystallized product.APPARATUS/INSTRUMENT REQUIRED: Reflux condenser round bottomed flask beaker glass rod pipette buchner funnel filtering flask water bath watch glass capillary tube thiele’s tube thermometer electronic balance vacuum pump and filter paper.CHEMICALS REQUIRED: Acetyl acetone hydrazine hydrate ethyl alcohol and n-hexane/petroleum ether.CHEMICAL REACTION: REACTION MECHANISM: PRINCIPLE: Substituted pyrazoles are prepared by condensation of 13-diketones with hydrazine. For example acetyl acetone and hydrazine gives 35-dimethyl pyrazole. The enamine and imine formed undergo cyclization to yield the product.PROCEDURE: 1. Take 0.06 moles of hydrazine hydrate in a 250 ml flask.2. To this add 25 mL of ethyl alcohol with constant stirring.3. Now place the flask in an ice-old water or ice-bath and wait for 10 minutes.