MERS-CoV

Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging zoonotic coronavirus. First identified in 2012 MERS-CoV has caused over 2460 infections and a fatality rate of about 35% in humans. Similar to severe acute respiratory syndrome coronavirus (SARS-CoV) MERS-CoV likely originated from bats; however different from SARS-CoV which potentially utilized palm civets as its intermediate hosts MERS-CoV likely transmits to humans through dromedary camels. Animal models such as humanized mice and nonhuman primates have been developed for studying MERS-CoV infection. Currently there are no vaccines and therapeutics approved for the prevention and treatment of MERS-CoV infection although a number of them have been developed preclinically or tested clinically. This book covers one editorial and 16 articles (including seven review articles and nine original research papers) written by researchers working in the field of MERS-CoV. It describes the following three main aspects: (1) MERS-CoV epidemiology transmission and pathogenesis; (2) current progress on MERS-CoV animal models vaccines and therapeutics; and (3) challenges and future prospects for MERS-CoV research. Overall this book will help researchers in the MERS-CoV field to further advance their work on the virus. It also has important implications for other coronaviruses as well as viruses outside the coronavirus family with pandemic potentials.