Metal Ions in Biological Systems

"Highlights the availability of magnesium to organisms, its uptake and transport in microorganisms and plants as well as its role in health and disease of animals and humans including its toxicology." Manganese in natural waters and earth's crust - its availability to organisms; manganese transport in micro-organisms; manganese uptake and transport in plants; manganese metabolism in animals and humans including the toxicity of manganese; interrelations between manganese and other metal ions in health and disease; the use of manganese as a probe for elucidating the role of magnesium ions in ribozymes; Mn2+ as a probe of divalent metal ion binding and function in enzymes and other proteins; enzymes and proteins containing manganese - an overview; manganese (II) in concanavalin and other lectin proteins; manganese-activated phosphatases; manganese (II) as a probe for the mechanism and specificity of restriction endonucleases; the role of the binuclear manganese (II) site in xylose isomerase; arginase - a binuclear manganese metalloenzyme; the use of model complexes to elucidate the structure and function of manganese redox enzymes; manganese (II)-dependent extradiol-cleaving catechol dioxygenases; manganese catalases; manganese peroxidase; manganese superoxide dismutase; mechanistic aspects of the tyrosyl radical-manganese complex; the polypeptides of photosystem II and their influence on mangonotyrosyl-based oxygen evolution.