Methods of Determination of Some Oral Hypoglycemic Drugs

Different methods for determination of some oral hypoglycemic drugs have been introduced in this book. These drugs are alogliptin benzoate linagliptin metformin hydrochloride saxagliptin hydrochloride sitagliptin phosphate and vildagliptin. Chromatographic part included determination of sitagliptin phosphate in bulk and in plasma using fluorimetric detection in the presence of sitagliptin acid degradation product after its preparation and structure elucidation and in its ternay mixture with metformin hydrochloride and sitagliptin acid degradation product using ultraviolet detection. Besides simultaneous determination of each of three novel gliptins; sitagliptin phosphate vildagliptin saxagliptin hydrochloride and metformin hydrochloride in the presence of metformin impurity (cyanoguanidine) was developed. And determination of linagliptin using ultraviolet detection and fluorimetric detection was also developed. Simultaneous determination of linagliptin and metformin hydrochloride and determination of alogliptin benzoate using ultraviolet detection was also developed.