Microwave-assisted CAN promoted synthesis of poly-substituted pyridine

This book compiles with the microwave-assisted synthesis characterization and in vitro antimicrobial evaluation of 246-trisubstituted pyridine derivatives catalyzed by ceric ammonium nitrate (CAN) also the effect of halogen substitution on antimicrobial activities. This synthetic study involves one pot cyclo-condensation reaction of 3-substituted-1H-pyrazole-4-carbaldehyde 1a-d and various substituted acetophenone 7a-d under microwave irradiation catalyzed by ceric ammonium nitrate (CAN) to gives 246-trisubstituted pyridine derivatives 8a-p. So it is worthy to narrate brief introduction regarding CAN and synthetic and biological consequence of the 246-trisubstituted pyridine (polysubstituted pyridine) derivatives.