Microwave assisted synthesis and antimicrobial evaluation

Heterocyclic compounds represent an important class of biological active molecules. Specifically those containing quinoxaline derivatives have evoked considerable attention in recent years as these are endowed. Quinoxalines are a versatile class of nitrogen containing heterocyclic compounds and they constitute useful intermediates in organic synthesis. Quinoxaline also called a benzopyrazine in organic chemistry is a heterocyclic compound containing a ring complex made up of a benzene ring and a pyrazine ring and they are isomeric with cinnolenes phthalazines and quinazolines. There are a number of processes available to generate quinoxaline but generally they are synthesized by the condensation of 1 2-dicarbonyls with 12 diamines in presence of suitable catalyst using various solvent systems. They possess well known biological activities including AMPA/GlyN receptor antagonis antihistaminic agents anti-trypanosomal activity anti-herps antiplasmodial activity Ca uptake/ Release inhibitor inhibit vascular smooth muscle cell proliferation.