MISOPROSTOL IN CERVICAL RIPENING

Premature rupture of the membranes is a frequent obstetrical condition. It affects 8 to 10% of full-term pregnancies and its optimal management is controversial. Among the agents used to promote cervical ripening are prostaglandins of which Dinoprostone is the reference molecule.Material and methods This is a prospective randomized clinical trial conducted at the maternity and neonatology center of Monastir University Hospital over a period of 1 year (January-December 2017).Including 240 parturients presenting with RPM at term and divided into 2 groups:The oral route group: having received 20mcg/ 2h misoprostol solution orally (maximum 6 doses) and the vaginal route group:having received 50mcg/ 6h misoprostol vaginally (maximum 4 doses).Conclusion At the end of this study the use of low-dose misoprostol by VO for cervical ripening at term with PDER is as effective as VV in terms of the rate of deliveries within 24 h while it is slightly ahead at 12 h (44% versus 33%) without the difference being significant.