Modeling and Analysis of Signal Transduction Networks

<p>Biological pathways such as signaling networks are a key component of biological systems<br />of each living cell. In fact malfunctions of signaling pathways are linked to a number of<br />diseases and components of signaling pathways are used as potential drug targets. Elucidating<br />the dynamic behavior of the components of pathways and their interactions is one of the key<br />research areas of systems biology.<br />Biological signaling networks are characterized by a large number of components and an<br />even larger number of parameters describing the network. Furthermore investigations of<br />signaling networks are characterized by large uncertainties of the network as well as limited<br />availability of data due to expensive and time-consuming experiments. As such techniques<br />derived from systems analysis e.g. sensitivity analysis experimental design and parameter<br />estimation are important tools for elucidating the mechanisms involved in signaling networks.<br />This Special Issue contains papers that investigate a variety of different signaling networks via<br />established as well as newly developed modeling and analysis techniques.</p>