<p><span style=color: rgba(23 43 77 1)>This second Special Issue on the&nbsp;</span><em style=color: rgba(23 43 77 1)>Molecular and Cellular Mechanisms of Glioblastoma</em><span style=color: rgba(23 43 77 1)>&nbsp;presents 16 articles on the biology genetics and possible treatments against this devastating disease. Pathways to gliomagenesis and new targets&nbsp;were explored along with epigenetic possibilities like the inhibition of HDAC and the role of miRNA and circular RNA tumor cell dormancy cancer stem cells and other approaches to try to better understand and possibly combat glioblastoma.</span></p>